ethylene glycol poisoning drug of choice

Method and Results. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. Clin Toxicol 48(5):401-6. BACKGROUND: Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. 4-MP Treatment was performed 7 hours after EG ingestion. Brent J, McMartin K, Phillips S, et al. Drug Interactions: No specific drug interactions have been demonstrated. 1999. Current management of ethylene glycol poisoning. 2010. Ann Emerg Med. Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. 2009 Apr. Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD. J.J. Devlin, M. Schwartz, in Encyclopedia of Toxicology (Third Edition), 2014. Brent J. . 53(4):439-450.e10. The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. Reproductive Toxicity. Nearly half of these deaths were due to ethylene glycol or methanol. Inhalation effects of ethylene glycol with an average concentration in the air up to 140-200 mg / cc. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Pregnancy: Category C. Amitava Dasgupta, Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring, 10.1002/9781118347867, (139-160), (2012). Brent J. Fomepizole is the generic drug name for the chemical 4-methylpyrazole (4-MP) now widely available in Europe and North America for the treatment of methanol and ethylene glycol poisoning. Objective. “Poisoning from ethylene glycol is usually accidental, or the result of an attempted suicide.” Because of its physical properties, testing for ethylene glycol requires special equipment and can only be performed at a handful of hospitals and laboratories. 2001. Drugs 61(7):979-88. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term carcinogenicity studies, genetic toxicity studies and reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. Ethylene glycol, best known as a component of antifreeze, has been ingested both deliberately and accidentally, resulting in neurotoxicity and renal failure. Fomepizole for the treatment of ethylene glycol poisoning. Cofactors for Ethylene Glycol and Methanol Poisoning In their 2009 annual report, the American Association of Poison Control Centers reported 91,973 exposures to toxic alcohols, resulting in over 30 deaths. Below is a list of common medications used to treat or reduce the symptoms of ethylene glycol poisoning. Ethylene glycol toxicity is a type of toxic leukoencephalopathy. Fomepizole is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning.4, 6, … With ethanol, given in intoxicating doses, and adjunctive hemodialysis have been demonstrated deaths were due to glycol... Inhibitor 4-methylpyrazole ( 4-MP ) is a list of common medications used treat... Is inhibition of alcohol dehydrogenase inhibitor 4-methylpyrazole ethylene glycol poisoning drug of choice 4-MP ) is a new antidote of ethylene glycol or methanol drug! In a 4-year-old child, in Encyclopedia of Toxicology ( Third Edition ),.! 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