styrene carcinogen classification

Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. The classification of styrene as, “reasonably anticipated to be a human carcinogen,” would have a major impact not only on the individuals employed, but the communities served. • Styrene is not classified as a carcinogen at the EU level. Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route Styrene has been tested for its potential to cause cancer in humans. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Styrene (CASRN 100-42-5). determination that Styrene does not cause cancer in humans. It often contains other chemicals that give it a sharp, unpleasant smell. In particular when there are disparities as regards their classification as well as … Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. 121 agents. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. Health effects of styrene include irritation of the skin, eyes, and the upper respiratory tract. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. The court also concluded, however, that styrene and vinyl acetate's IARC Group 2B category did not mean that they were "known carcinogens" in the State of California and thus they could not be included on the Proposition 65 list by virtue of the IARC classification alone. The National Toxicology Program (NTP) has classified styrene as "reasonably anticipated to be a human carcinogen." In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. Learn More OK Styrene (CASRN 100-42-5). Donate now. P ag e 6 of 9 MSDS -STYRENE 10. View The Lancet Oncology summary as HTML or PDF. (13) Styrene oxide is a reactive metabolite of styrene and shows positive carcinogenic results in oral exposure bioassays. ToxFAQs™ for Styrene. Staff. • SIRC will submit additional studies to … Reinforced-Plastics Industry In the multinational study of reinforced-plastics workers, work In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! Note however that this classification is based on chronic non-lethal exposure, not on acute exposure. It's a colorless liquid that evaporates easily and has a sweet smell. NTP classification: Reasonably anticipated to be a humans carcinogen. OSHA has reviewed additional evidence and has determined that the most appropriate basis for classifying styrene in this rulemaking is the substance’s demonstrated narcotic effects. Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies together with new animal evidence. Dr. Tardiff reported that the SAB had advised EPA to consider styrene a “possible human carcinogen (Category C) at best” (Ex. Thus, at this time, OSHA believes that the current evidence on styrene’s carcinogenicity does not support its classification in the final rule as a carcinogen. Low levels of styrene also occur naturally in a variety of foods such as fruits, vegetables, nuts, beverages, and meats. Styrene is categorized as a “reasonably anticipated carcinogen.” The schedule for filings ordered by the court is: • Oct. 7, the government’s motion for a summary judgment request the court to rule in the government’s favor; News. 100-42-5) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). NTP: Reasonably anticipated to be a human carcinogen . NTP classification: Reasonably anticipated to be a humans carcinogen. Potential carcinogen: comes from a harmonised C&L classifying the substance as a suspected carcinogen Carc.2. Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. Styrene 7,8-oxide is a major metabolite of styrene and has been evaluated previously (IARC, 1994b). The International Agency for Research on Cancer (IARC) has given styrene a classification of 2B (Possibly Carcinogenic … Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route The Report on Carcinogens is a congressionally mandated, science-based, public health document that NTP prepares for the HHS Secretary. Addendum to the Toxicological Profile for Styrene (September 2011). Meetings. The International Agency for Research on Cancer (IARC) have devised a system of categories to evaluate the carcinogenicity of an agent to humans.An agent is classified based on scientific evidence derived from human and experimental animal studies and from mechanistic and other relevant data.The list of categories and their definition are shown in Table 1. Styrene oxide has been detected in workers exposed to styrene. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). A news article in the peer-reviewed journal The Lancet Oncology, … Based on that classification, the European Commission asked EFSA to re-evaluate the safety of styrene for use in in plastic FCMs. 89 agents. 1. [2] Possibly carcinogenic to humans. The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. The update of EPA's carcinogen risk a… Agents Classified by the IARC Monographs, Volumes 1–128. Answers the most frequently asked health questions about styrene. Contact. In particular when there are disparities as regards their classification as well as … Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). Lawsuit to be decided in early 2012. The following references aid in recognizing occupational hazards and health effects associated with styrene. Styrene has been Styrene has been classified possibly carcinogenic - Group 2B by IARC. More . Styrene was tested for carcinogenicity in rats in four gavage studies, one drinking-water study and two inhalation studies. Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. It is also known as vinylbenzene, ethenylbenzene, cinnamene, or phenylethylene. French version of The Lancet Oncology summary (hosted by Centre Léon Bérard). The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. Publications. Occupational Safety & Health Administration, Occupational Safety and Health Administration, Criteria for a Recommended Standard: Occupational Exposure to Styrene, International Chemical Safety Cards (ICSC), Severe Storm and Flood Recovery Assistance. In general, these limitations make it more difficult to see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer across studies. Group 1. This website uses cookies to give you the best experience. 1. Now, according to the International Agency for Research on Cancer (IARC), styrene is “probably carcinogenic to humans.” [1] Styrene was previously classified as “possibly carcinogenic to humans.” Research shows that workplace styrene exposure doubles the risk of leukemia, and increases the risk of a certain type of nasal cancer by 5 times. Dr. Tardiff further commented that the Category C classification “would generally lead EPA to regulate the compound based on … Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Mechanistic Studies: Exactly how styrene causes cancer is not fully understood, but styrene is converted, in laboratory animals and humans, to styrene–7,8–oxide, which is listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen. The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. In September 2019, IARC updated its evaluation of styrene to classify the substance as “probably carcinogenic to humans” (Group 2A). Overall, there was no reliable evidence for an increase in tumour incidence in rats. NTP: Reasonably anticipated to be a human carcinogen . Some epidemiologic studies suggest there may be an association between styrene exposure and an increased risk of leukemia and lymphoma, but EPA has not given a formal carcinogen classification to styrene. IARC: Possibly carcinogenic to humans. The National Toxicology Program of the U.S. Department of Health and Human Services has determined that styrene is "reasonably anticipated to be a human carcinogen". This volume of the IARC Monographs provides evaluations of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide.. Quinoline and styrene are present in air pollution and in tobacco smoke. Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). 1. Answers the most frequently asked health questions about styrene. Styrene. Preamble. • SIRC will submit additional studies to … Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). Styrene is regarded as a "known carcinogen ", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. This cumulative report currently includes 248 listings of agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans. Styrene. Appellate Court Opinion 34, p. 4). Styrene Classified as Carcinogen April 25, 2016 Effective April 22, 2016, California's Office of Environmental Health Hazard Assessment (OEHHA) has added styrene (CAS No. Lawsuit to be decided in early 2012. A news article in the peer-reviewed journal The Lancet Oncology, … Most of these products contain styrene linked together in a long chain (polystyrene) as well as unlinked styrene. Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). EPA has since gained considerable experience in applying cancer risk assessment approaches. Carcinogen Classification Systems: A Time for Change (Robert J. Moolenaar) ... At the present time, there is no clear evidence that styrene is carcinogenic in man or laboratory animals, but the available data are inadequate to reach definitive conclusions. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Carcinogenic to humans. (7,12) Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Note: Javascript is disabled or is not supported by your browser. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. Group 2A. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. In 2011, the styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a 'poison scandal' in the Danish media. adding styrene to the Proposition 65 list as a known carcinogen for two general reasons: 1. EPA's first carcinogen risk assessment guidelines [1], published in 1986, were the product of nearly two decades of experience and scientific consensus building. • Styrene is not classified as a carcinogen at the EU level. List of Classifications. Concurrently, the science of risk assessment and toxicological testing has continued to evolve, and EPA has had to address situations not explicitly discussed in the 1986 guidelines, e.g., children's risk assessment. Billions of pounds are produced each year to make products such as rubber, plastic, insulation, fiberglass, pipes, automobile parts, food containers, and carpet backing. Human studies are inconclusive on the reproductive and developmental effects of styrene. Adding styrene to the Proposition 65 list of known carcinogens would be contrary to law. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. Group 2B. The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. Styrene-7,8-oxide causes genetic damage and has been found in the blood of workers exposed to styrene. topoietic cancer classification and groupings have changed over time. Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). [44] IARC has classified this metabolite as a Group 2A, probable human carcinogen. Acute exposure may also result in gastrointestinal effects. CHRONIC EFFECTS: A component (styrene) is suspected reproductive toxin. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. Summary: Styrene is primarily a synthetic chemical. The U.S. EPA does not have a cancer classification for styrene, but it has been the subject of their Integrated Risk Information System (IRIS) program. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. B. Styrene Is Not a Carcinogen. Classifications. IARC has classified styrene as a Group 2A, probably carcinogenic to humans. For this reason, some items on this page will be unavailable. Broad agreement: comes from industry data where a majority of data submitters agree the substance is carcinogenic. Chronic exposure affects the central nervous system showing symptoms such as depression, headache, fatigue, weakness, and may cause minor effects on kidney function. Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). IARC: Possibly carcinogenic to humans. It dissolves in some liquids but doesn't dissolve easily in water. determination that Styrene does not cause cancer in humans. Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450. P ag e 6 of 9 MSDS -STYRENE 10. Styrene is not a carcinogen and no scientific body has ever said it was; 2. Probably carcinogenic to humans. ToxFAQs™ for Styrene. Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. IARC classifications. • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. A known carcinogen for two general reasons: 1 ( 13 ) styrene oxide in humans One... Fruits, vegetables, nuts, beverages, and the result of a process. Ethenylbenzene, cinnamene, or EPA ’ s IRIS Hotline with questions on cancer and cancer classification groupings! 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